aTyr Pharma, Inc. (ATYR) Securities Class Action

The suits allege that aTyr and its top executives made false and misleading statements about the efficacy of its drug, Efzofitimod, leading investors to purchase stock at artificially inflated prices.

At the heart of the allegations is aTyr’s Phase 3, randomized, double-blind, placebo-controlled study, known as EFZO-FIT, which evaluated intravenous Efzofitimod in patients with pulmonary sarcoidosis. The drug was intended to help patients reduce their dependency on steroids.

According to the complaint, throughout the Class Period, aTyr executives expressed overwhelmingly positive statements and confidence in the study’s design, particularly its forced taper approach intended to gauge the drug’s ability to allow patients to completely wean themselves off steroids.

However, the lawsuit claims that concurrently with these optimistic pronouncements, the company was allegedly concealing material adverse facts concerning Efzofitimod’s capability to allow a patient to completely taper their steroid usage—a key measure of efficacy.  The lawsuit asserts that aTyr’s statements crossed the line into securities law violations by allegedly misrepresenting the drug’s true prospects.

The truth, as alleged in the complaint, came to light on Monday, September 15, 2025. Pre-market, aTyr hosted an investor call announcing that the EFZO-FIT study did not meet its primary endpoint: the change from baseline in mean daily oral corticosteroid (OSC) dose at week 48.

The disappointing topline results prompted a swift and brutal market reaction. aTyr’s common stock, which had closed at $6.03 per share on the preceding Friday, September 12, cratered to close at just $1.02 per share on September 15—a catastrophic one-day decline of 83.2%.

In its post-announcement comments, the company stated that it would engage with the Food and Drug Administration (FDA) to determine a path forward, acknowledging the setback.

FREQUENTLY ASKED QUESTIONS ABOUT THE CASE

What is the ATYR investigation about?

We are scrutinizing whether aTyr’s previous representations about the drug’s efficacy were materially misleading to investors.

WHAT SHOULD I DO?

I worked at ATYR. What should I do?

If you were an employee of ATYR, you may have valuable information that could be relevant to the investigation. Hagens Berman is one of the nation’s top whistleblower law firms, and has successfully represented many individuals who come forward with information regarding corporate malfeasance. Under the new SEC Whistleblower program, whistleblowers who provide original information may receive rewards totaling up to 30 percent of any successful recovery made by the SEC. For more information, contact Reed Kathrein at 844-916-0895 or ATYR@hbsslaw.com.

There are multiple law firms participating, do I need to contact all of them?

No, you do not need to contact all participating law firms. Generally, class-action investigations and lawsuits are consolidated into a single case to streamline the legal process, and attorneys from only a few law firms are selected to serve in a leadership role on the consolidated case. Hagens Berman has a proven track record of being appointed to leadership roles in complex, multidistrict litigation regarding investor fraud and other consumer rights issues, and your claim will be handled by attorneys who have helped secure approximately $325 billion in class-action settlements on behalf of individuals who have suffered due to corporate malfeasance and the wrongdoing of other powerful institutions.

AM I ELIGIBLE?

What is the threshold amount to be eligible? What are “substantial” losses?

The threshold amount and the definition of "substantial" losses may vary depending on a number of factors specific to the case, including the size of the company, market cap, shares outstanding and who holds them and the damages alleged by the fraud. In general, to be eligible to participate in a class-action lawsuit, you must be able to demonstrate that you suffered financial losses as a result of the alleged wrongdoing and that your losses meet the criteria set by the court or law firm. Fill out the form and submit your losses.

CAN I PARTICIPATE?

Am I affected? What do I need to do to participate?

If you were an investor in ATYR, you may be affected and eligible to participate in the case. To determine your eligibility and potential involvement, fill out the form and submit your losses.

Can any ATYR investor participate?

In most class-action investigations and cases, any investor who meets the eligibility criteria, including purchasing the shares during the relevant period, can participate, regardless of the size of their investment. Fill out the form to find out your rights.

I bought on a non-U.S. Exchange. Can I participate?

No. This investigation only covers shares bought on a U.S. exchange, i.e. NASDAQ or NYSE. Fill out the form to find out your rights.

Am I included if I still hold my shares, or do I need to sell to participate?

Participation is based on purchasing shares during the relevant period, rather than your current holdings. Accordingly, you do not need to sell to participate. Fill out the form to find out your rights.